Table 4.

Subgroup analysis according to Scr.

Variables	No. of studies	No. of participants	SMD [95%CI]	P value
Duration
< 12 weeks	11	209	-2.11 [-2.87, -1.36]	0.48
?12 weeks	14	222	-1.74 [-2.42, -1.06]
Dosage
High dose	17	277	-1.89 [-2.61, -1.17]	0.53
Medium dose	5	94	-2.18 [-2.72, -1.64]
Low dose	3	60	-1.71 [-2.34, -1.10]
Models of animals
Type 1 DN	7	108	-1.35 [-2.27, -0.43]	0.17
Type 2 DN	11	235	-2.40 [-3.11, -1.69]
NR	7	88	-1.60 [-2.66, -0.55]
Species
Rat	15	281	-1.92 [-2.53, -1.31]	0.97
Mice	10	150	-1.90 [-2.78, -1.01]