Table 2.
Time to Onset of Treatment Response by Treatment Group
| Days postinjection | ASI 50 U (N = 125) | Placebo (N = 58) | ||
|---|---|---|---|---|
| Onset of response, n (%) | Cumulative nonresponse ratea, % (95% CI) | Onset of response, n (%) | Cumulative nonresponse ratea, % (95% CI) | |
| 1 | 26 (20.8) | 79 (71, 85) | 6 (10.3) | 90 (78, 95) |
| 2 | 32 (25.6) | 54 (44, 62) | 0 | — |
| 3 | 17 (13.6) | 40 (31, 48) | 3 (5.2) | 84 (72, 92) |
| 4 | 12 (9.6) | 30 (23, 39) | 2 (3.4) | 81 (68, 89) |
| 5 | 6 (4.8) | 26 (18, 33) | 0 | — |
| 6 | 5 (4.0) | 21 (15, 29) | 0 | — |
| 7 | 1 (0.8) | 20 (14, 28) | 0 | — |
| >7 or no response | 25 (20.0) | — | 47 (81.0) | — |
Onset of response is defined as the first day patient responds “yes” to the question “Since being injected have you noticed an improvement in the appearance of your glabellar lines (lines between your eyebrows)?” ASI, abobotulinumtoxinA solution for injection; CI, confidence interval. aPercent of patients who had not responded by postinjection day, determined by Kaplan-Meier estimates.