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. Author manuscript; available in PMC: 2019 Dec 20.
Published in final edited form as: J Med Chem. 2019 Aug 1;62(16):7557–7574. doi: 10.1021/acs.jmedchem.9b00869

Scheme 1. Synthesis of 5–7 and 10a.

Scheme 1.

aReagents and conditions: (a) tetrahydrofuran (THF), 0 °C to room temperature (rt), 48–67%; (b) dioxane, reflux, 1 h, 56–96%; (c) Pd(PPh3)4, K2CO3, dioxane/H2O = 5:3, 120 °C, microwave, 20 min, 42–98%.