Table I.
Ferroptosis in associated types of digestive system cancer.
| A, Pancreatic cancer | ||||
|---|---|---|---|---|
| Author, year | Compound | Target | Effect | (Refs.) |
| Eling et al, 2015 | Artesunate | Ferritinophagy | Induces ferroptosis | (14) |
| Hou et al, 2016 | Nuclear receptor coactivator 4 | Ferritinophagy | Induces ferroptosis | (42) |
| Shintoku et al, 2017 | ALOX15 activator | Lipid oxidation | Induces ferroptosis | (50) |
| Krainz et al, 2016 | XJB-5-131, JP4-039 | Mitochondrial lipid oxidation | Inhibits ferroptosis | (54) |
| Kasukabe et al, 2016 | Cotylenin A, phenethyl isothiocyanate | ROS accumulation | Induces ferroptosis | (15) |
| Yamaguchi et al, 2018 | Piperlongumine | ROS accumulation | Induces ferroptosis | (58) |
| Wang et al, 2016 | Dopamine | GSH depletion and Fe2+ reduction | Inhibits ferroptosis | (57) |
| Xie et al, 2016 | Baicalein | GSH depletion and Fe2+ reduction | Inhibits ferroptosis | (13) |
| Zhu et al, 2017 | Heat shock 70 kDa protein 5 | GPX4 pathway | Inhibits ferroptosis | (38) |
| Lachaier et al, 2014 | Sorafenib | System Xc- | Induces ferroptosis | (70) |
| Song et al, 2018 | Beclin 1 | System Xc- | Induces ferroptosis | (72) |
| B, Hepatocellular carcinoma | ||||
| Author, year | Compound | Target | Effect | (Refs.) |
| Yuan et al, 2016 | Acyl-CoA synthetase long-chain family member 4 | Lipid oxidation | Induces ferroptosis | (30) |
| Bai et al, 2017 | Haloperidol | Lipid peroxidation and Fe2+ accumulation | Induces ferroptosis | (73) |
| Chang et al, 2018 | BAY 11e7085 | Nuclear factor (erythroide-derived 2)-like 2 pathway | Induces ferroptosis | (75) |
| Louandre et al, 2015 | Retinoblastoma | Mitochondrial lipid oxidation | Inhibits ferroptosis | (76) |
| Ou et al, 2017 | Low-density lipoprotein-docosahexaenoic acid nanoparticles | GSH depletion and GPX4 degradation | Induces ferroptosis | (77) |
| Yuan et al, 2016 | CDGSH iron sulfur domain 1 | Mitochondrial lipid oxidation | Inhibits ferroptosis | (74) |
| Jennis et al, 2016 | TP53 | System Xc- | Inhibits ferroptosis | (78) |
| C, Colorectal cancer | ||||
| Author, year | Compound | Target | Effect | (Refs.) |
| Guo et al, 2018 | Cisplatin | GSH depletion and GPX4 degradation | Induces ferroptosis | (79) |
| Xie et al, 2017 | TP53 | System Xc-, lipid oxidation | Inhibits ferroptosis | (80) |
ROS, reactive oxygen species; GSH, glutathione; GPX4, glutathione peroxidase 4; TP53, cellular tumor antigen p53; ALOX15, arachidonate 15-lipoxygenase.