Table 4.

Enriched biological processes of hypermethylated genes in SO compared to SOA (> 20% methylation difference, n = 40)

#term ID	Term description	Observed gene count	False discovery rate
GO:0048846	Axon extension involved in axon guidance	3	0.0012
GO:0009987	Cellular process	35	0.0027
GO:0050919	Negative chemotaxis	3	0.0125
GO:0070100	Negative regulation of chemokine-mediated signaling pathway	2	0.0125
GO:0021825	Substrate-dependent cerebral cortex tangential migration	2	0.0135
GO:0035385	Roundabout signaling pathway	2	0.0135
GO:0060560	Developmental growth involved in morphogenesis	4	0.0135
GO:0023052	Signaling	17	0.0139
GO:0007154	Cell communication	17	0.0185
GO:0007268	Chemical synaptic transmission	5	0.0185
GO:0042118	Endothelial cell activation	2	0.0185
GO:1902668	Negative regulation of axon guidance	2	0.0185
GO:0003180	Aortic valve morphogenesis	2	0.0244
GO:0022008	Neurogenesis	10	0.0244
GO:0001657	Ureteric bud development	3	0.0322
GO:0001964	Startle response	2	0.0387
GO:0007399	Nervous system development	11	0.0387
GO:0035235	Ionotropic glutamate receptor signaling pathway	2	0.0387
GO:0048699	Generation of neurons	9	0.0387
GO:0050789	Regulation of biological process	27	0.0387
GO:0050794	Regulation of cellular process	26	0.0387
GO:0090287	Regulation of cellular response to growth factor stimulus	4	0.0387
GO:0120033	Negative regulation of plasma membrane bounded cell projection assembly	2	0.0387
GO:0008045	Motor neuron axon guidance	2	0.0398
GO:0030182	Neuron differentiation	7	0.0398
GO:0030517	Negative regulation of axon extension	2	0.0398
GO:0035249	Synaptic transmission, glutamatergic	2	0.0398
GO:0090288	Negative regulation of cellular response to growth factor stimulus	3	0.046
GO:0007267	Cell-cell signaling	6	0.049
GO:0021884	Forebrain neuron development	2	0.0494