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. 2019 Dec 20;14:47. doi: 10.1186/s13024-019-0352-2

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© The Author(s). 2019

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 1 — Differences in microbial community between EFAD mice stratified by APOE, sex and APOE + sex. Analysis of β-diversity associated with (a) APOE, (b) sex and (c) APOE + sex in the GM of 4 M EFAD mice. PCoA plots with 95% confidence ellipses were generated based on the Bray-Curtis dissimilarity. Significant differences between cohorts were determined by PERMANOVA, with significance (bold) defined by p < 0.05. Additional file 1: Table S1 contains the complete PERMANOVA dataset