Table 2.
Levels of remodeling markers at baseline and after 12-months of intervention in the randomized groups
| Control | Exercise | ∆p | Relative ∆p | |||||
|---|---|---|---|---|---|---|---|---|
| Baseline | 12-months | p1 | Baseline | 12-months | p2 | |||
| AT-MMP9 | 1.98 (0.89, 3.26) | 1.61 (0.97, 3.50) | 0.586 | 1.57 (0.82, 3.05) | 1.18 (0.89, 1.91) | 0.184 | 0.650 | 0.767 |
| AT-TIMP1 | 1.02 (0.79, 1.15) | 1.08 (0.79, 1.43) | 0.476 | 0.96 (0.75, 1.30) | 0.99 (0.80, 1.45) | 0.495 | 0.908 | 0.929 |
| AT-EMMPPRIN | 0.99 (0.73, 1.28) | 0.82 (0.61, 1.25) | 0.021 | 0.86 (0.73, 1.06) | 0.95 (0.66, 1.26) | 0.146 | 0.008* | 0.018* |
| AT-Galectin-3 | 1.03 (0.69, 1.38) | 0.96 (0.64, 1.30) | 0.015 | 1.05 (0.83, 1.31) | 1.00 (0.70, 1.24) | 0.179 | 0.366 | 0.366 |
| L-MMP9 | 0.79 (0.57, 1.30) | 0.72 (0.47, 1.47) | 0.837 | 0.86 (0.60, 1.58) | 0.77 (0.61, 1.27) | 0.158 | 0.480 | 0.544 |
| L-TIMP1 | 0.98 (0.68, 1.61) | 1.04 (0.67, 1.64) | 0.654 | 1.09 (0.88, 1.71) | 0.96 (0.70, 1.63) | 0.313 | 0.822 | 0.434 |
| L-EMMPRIN | 0.66 (0.36, 1.00) | 0.61 (0.27, 1.24) | 0.599 | 0.63 (0.45, 1.03) | 0.60 (0.35, 0.82) | 0.035 | 0.271 | 0.388 |
| L-Galectin-3 | 0.94 (0.68, 1.35) | 0.94 (0.55, 1.41) | 0.273 | 1.04 (0.71, 1.35) | 0.80 (0.61, 1.29) | 0.030 | 0.284 | 0.411 |
| sMMP9 | 317 (198, 416) | 288 (189, 431) | 0.956 | 308 (215, 427) | 335 (257, 490) | 0.054 | 0.152 | 0.052 |
| sTIMP1 | 158 (140, 175) | 160 (143, 184) | 0.328 | 158 (140, 184) | 168 (149, 191) | 0.001 | 0.066 | 0.082 |
| sEMMPRIN | 3748 (3432, 4118) | 3707 (3515, 4100) | 0.908 | 3848 (3391, 4404) | 3983 (3452, 4521) | 0.007 | 0.033* | 0.036* |
| sGalectin-3 | 10.6 (8.1, 12.7) | 10.0 (8.3, 11.6) | 0.806 | 10.3 (8.3, 11.7) | 10.2 (8.6, 12.3) | 0.074 | 0.138 | 0.246 |
Values are median (25, 75 percentiles)
AT refers to gene expression in adipose tissue, L refers to gene expression in circulating leukocytes, s indicate serum
p1-values refer to changes within the control group from baseline to 12 months (Wilcoxon Signed Rank test)
p2-values refer to changes within the exercise group from baseline to 12 months (Wilcoxon Signed Rank test)
p-values in italics indicate statistically significant values
Delta p (Δp) refers to difference in change between the groups during intervention (Mann–Whitney test)
Relative delta p (Δp) refers to difference in change between the groups during intervention as related to baseline levels