Table I.
Clinicopathological characteristics of patients in different datasets.
| Characteristic | IHC cohort, n (%) | GSE13861, n (%) | GSE15456, n (%) | GSE15459, n (%) | GSE26253, n (%) | GSE26899, n (%) | GSE26901, n (%) | GSE29272, n (%) | GSE34942, n (%) | GSE35809, n (%) | GSE66229, n (%) | TCGA, n (%) |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Sex | ||||||||||||
| Total | 190 (100) | 65 (100) | 30 (100) | 192 (100) | 432 (100) | 92 (100) | 109 (100) | 134 (100) | 56 (100) | 70 (100) | 300(100) | 415(100) |
| Male | 144 (75.8) | 46 (70.8) | 17 (56.7) | 125 (65.1) | 280 (64.8) | 73 (79.3) | 69 (63.3) | 103 (76.9) | 36 (64.3) | 48 (68.6) | 199 (66.3) | 268 (64.6) |
| Female | 46 (24.2) | 19 (29.2) | 13 (43.3) | 67 (34.9) | 152 (35.2) | 19 (20.7) | 40 (36.7) | 31 (23.1) | 20 (35.7) | 22 (31.4) | 101 (33.7) | 147 (35.4) |
| Median age, years (min, max) | 59 (25, 85) | 63 (32, 83) | 73 (53, 83) | 66 (23, 92) | 53 (23, 74) | 59 (36, 83) | 58 (28, 74) | 59 (23, 73) | 69 (43, 84) | 67 (32, 85) | 64 (24, 86) | 67 (30, 90) |
| T stage | ||||||||||||
| 1 | 15 (7.9) | 2 (3.1) | – | 8 (4.2) | – | – | – | – | – | – | 2 (0.7) | 22 (5.3) |
| 2 | 32 (16.8) | 23 (35.4) | – | 45 (23.4) | – | – | – | – | – | – | 186 (62) | 88 (21.2) |
| 3 | 24 (12.6) | 34 (52.3) | – | 107 (55.7) | – | – | – | – | – | – | 91 (30.3) | 181 (43.6) |
| 4 | 119 (62.6) | 1 (1.5) | – | 1 (0.5) | – | – | – | – | – | – | 21 (7) | 115 (27.7) |
| Unknown | 0 (0) | 5 (7.7) | – | 31 (16.1) | – | – | – | – | – | – | 0 (0) | 9 (2.2) |
| TNM stage | ||||||||||||
| I | 29 (15.3) | 12 (18.5) | 6 (20) | 31 (16.1) | 68 (15.7) | 11 (12.0) | 38 (29.5) | 5 (3.7) | 11 (19.6) | 13 (18.6) | 31 (10.3) | 57 (13.7) |
| II | 60 (31.6) | 2 (3.1) | 4 (13.3) | 29 (15.1) | 167 (38.7) | 18 (19.6) | 40 (31) | 5 (3.7) | 11 (19.6) | 16 (22.9) | 97 (32.3) | 123 (29.6) |
| III | 91 (47.9) | 35 (53.8) | 15 (50) | 72 (37.5) | 130 (30.1) | 27 (29.3) | 36 (27.9) | 115 (85.8) | 19 (33.9) | 33 (47.1) | 95 (31.7) | 169 (40.7) |
| IV | 10 (5.3) | 16 (24.6) | 5 (16.7) | 60 (31.3) | 67 (15.5) | 36 (39.1) | 15 (11.6) | 9 (6.7) | 13 (23.2) | 7 (10) | 77 (25.7) | 41 (9.9) |
| Unknown | 0 (0) | 0 (0) | 0 (0) | 0 (0) | 0 (0) | 0 (0) | 0 (0) | 0 (0) | 2 (3.6) | 1 (1.4) | 0 (0) | 25 (6.0) |
| Tumor grade | ||||||||||||
| Low | 48 (24) | 20 (30.8) | 2 (6.7) | 6 (3.1) | – | – | – | 1 (0.7) | – | 2 (2.9) | – | 12 (2.9) |
| Intermediate | 66 (33) | 15 (23.1) | 13 (43.3) | 53 (27.6) | – | – | – | 48 (35.8) | – | 22 (31.4) | – | 148 (35.7) |
| High | 76 (38) | 6 (9.2) | 15 (50) | 86 (44.8) | – | – | – | 85 (63.4) | – | 26 (37.1) | – | 246 (59.3) |
| Undifferentiated | 10 (5) | 24 (36.9) | 0 (0) | 47 (24.5) | – | – | – | 0 (0) | – | 20 (28.6) | – | 9 (2.2) |
| Follow-up endpoint (death) | ||||||||||||
| Occurred | 101 (50.5) | – | – | 95 (49.5) | – | – | – | 31 (23.1) | 27 (48.2) | – | 159 (53) | 144 (34.7) |
| Not occurred | 99 (49.5) | – | – | 97 (50.5) | – | – | – | 95 (70.9) | 29 (51.8) | – | 141 (47) | 214 (51.6) |
| No data | 0 (0) | – | – | 0 (0) | – | – | – | 8 (6) | 0 (0) | – | 0 (0) | 57 (13.7) |
-, data not available; TNM, Tumor-Node-Metastasis.