Table IV.
Top 10 statistically meaningful biological processes associated with DC-SIGNR.
| Rank | Pathway ID | Pathway description | Matching proteins |
|---|---|---|---|
| 1 | GO.0002223 | Stimulatory C-type lectin receptor signaling pathway | DC-SIGN, HRAS, ICAM2, ICAM3, KRAS, NRAS, RAF1 |
| 2 | GO.0031347 | Regulation of defense response | DC-SIGN, HRAS, ICAM2, ICAM3, IL10, IL4, KRAS, NRAS, RAF1 |
| 3 | GO.0006952 | Defense response | DC-SIGN, CD83, HRAS, ICAM2, ICAM3, IL10, ITIH4, KRAS, NRAS, RAF1 |
| 4 | GO.0002376 | Immune system process | DC-SIGN, CD83, HRAS, ICAM2, ICAM3, IL10, IL4, KRAS, NRAS, RAF1 |
| 5 | GO.0006955 | Immune response | DC-SIGN, CD83, HRAS, ICAM2, ICAM3, IL10, KRAS, NRAS, RAF1 |
| 6 | GO.0050776 | Regulation of immune response | DC-SIGN, HRAS, ICAM2, ICAM3, IL10, KRAS, NRAS, RAF1 |
| 7 | GO.0002682 | Regulation of immune system processes | DC-SIGN, CD83, HRAS, ICAM2, ICAM3, IL10, KRAS, NRAS, RAF1 |
| 8 | GO.0002684 | Positive regulation of immune system processes | DC-SIGN, CD83, HRAS, ICAM2, ICAM3, KRAS, NRAS, RAF1 |
| 9 | GO.0045087 | Innate immune response | DC-SIGN, HRAS, ICAM2, ICAM3, IL4, KRAS, NRAS, RAF1 |
| 10 | GO.0000186 | Activation of MAPKK activity | HRAS, KRAS, NRAS, RAF1 |
DC-SIGNR, dendritic cell-specific intercellular adhesion molecule-grabbing non-integrin-related protein; MAPKK, mitogen-activated protein kinase kinase.