Table 2.
HPV presence and P16INK4A expression in penile squamous cell carcinomas
| Total | HPV- | HPV+ | HPV MG | P6INK4A+ | P16INK4A- | |||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| n | % | n | % | n | % | n | % | n | % | n | % | |
| HPV-non-related carcinoma | 45 | 75.0 | 17 | 41.5 | 24 | 58.5 | 5 | 20.8 | 11 | 27.5 | 29 | 72.5 |
| Squamous cell carcinoma usual | 38 | 63.3 | 15 | 42.9 | 20 | 57.1 | 4 | 20.0 | 11 | 32.4 | 23 | 67.6 |
| Verrucous | 4 | 6.7 | 1 | 25.0 | 3 | 75.0 | 0 | 0.0 | 0 | 0.0 | 4 | 100.0 |
| Papillary NOS | 1 | 1.7 | 1 | 100.0 | 0 | 0.0 | 0 | 0.0 | 0 | 0.0 | 1 | 100.0 |
| Sarcomatoid | 1 | 1.7 | N.D. | N.D. | N.D. | N.D. | N.D. | |||||
| Mixed | 1 | 1.7 | 0 | 0.0 | 1 | 100.0 | 1 | 100.0 | 0 | 0.0 | 1 | 100.0 |
| HPV-related penile carcinoma | 15 | 25.0 | 6 | 40.0 | 9 | 60.0 | 5 | 55.6 | 6 | 40.0 | 9 | 60.0 |
| Basaloid | 7 | 11.3 | 2 | 28.6 | 5 | 71.4 | 3 | 60.0 | 5 | 71.4 | 2 | 28.6 |
| Warty | 8 | 13.3 | 4 | 50.0 | 4 | 50.0 | 2 | 50.0 | 1 | 12.5 | 7 | 87.5 |
| Histologycal grade | ||||||||||||
| Grade 1 | 27 | 45.0 | 16 | 61.5 | 10 | 38.5 | 3 | 30.0 | 3 | 12.5 | 21 | 87.5 |
| Grade 2 | 25 | 41.7 | 7 | 30.4 | 16 | 69.6 | 4 | 25.0 | 9 | 37.5 | 15 | 62.5 |
| Grade 3 | 8 | 3.3 | 0 | 0.0 | 7 | 100.0 | 3 | 42.9 | 5 | 71.4 | 2 | 28.6 |
| p = 0.0053 | p = 0.0079 | |||||||||||
The histological classification was carried out according to the WHO 2016 criteria. The HPV detection was performed using Inno-Lipa, only 56 cases were valid. Regarding P16INK4A, the evaluation was performed in 55 cases. Statistically significant differences are indicated p < 0.05 (chi square test)
HPV MG HPV multiple genotypes, N.D Not determinate