Table IV.
Univariate and multivariate Cox regression analysis to predict MIBC progression.
| Univariate Cox analysis | Multivariate Cox analysis | |||
|---|---|---|---|---|
| Variables | HR (95% CI) | P-value | HR (95% CI) | P-value |
| Age | ||||
| ≤70 (Ref.) vs. >70 | 1.302 (0.432–3.926) | 0.639 | ||
| Sex | ||||
| Male (Ref.) vs. female | 5.625 (1.766–17.912) | 0.003a | 7.255 (2.062–25.528) | 0.002a |
| Operation | ||||
| TURBT (Ref.) vs. Radical cystectomy | 0.948 (0.309–2.905) | 0.926 | ||
| Tumor size | ||||
| ≤1 cm | Ref. | 0.406 | ||
| 2–3 cm | 12417.036 (0.000–2.033×10143) | 0.954 | ||
| >3 cm | 35009.555 (0.000–5.718×10143) | 0.949 | ||
| Multiplicity | ||||
| Single | Ref. | 0.507 | ||
| 2–7 | 0.358 (0.046–2.800) | 0.328 | ||
| >7 | 1.483 (0.324–6.787) | 0.611 | ||
| 2004 WHO Grade | ||||
| Low (Ref.) vs. high | 31.010 (0.132–7298.224) | 0.218 | ||
| Stage | ||||
| T2 | Ref. | 0.851 | ||
| T3 | 1.630 (0.297–8.958) | 0.574 | ||
| T4 or N1 or M1 | 1.229 (0.358–4.222) | 0.744 | ||
| Chemotherapy | ||||
| No (Ref.) vs. yes | 3.912 (1.076–14.218) | 0.038a | 2.859 (0.752–10.868) | 0.123 |
| ARHGAP9 expression High expression (Ref.) vs. Low expression | 3.818 (1.145–12.733) | 0.029a | 5.241 (1.456–18.870) | 0.011a |
a
P<0.05. MIBC, muscle invasive bladder cancer; CI, confidence interval; HR, hazard ratio; Ref., reference; ARHGAP9, Rho GTPase-activating protein 9.