Table II.

Typical cancer-associated lncRNAs identified by high-throughput sequencing.

Author, year	LncRNA	Cancer type	Biological function	Mechanism	(Refs.)
Tseng et al, 2014	PVT1	Breast, ovarian and hepatocellular	Promotes proliferation	Controls Myc levels by regulating protein stability	(7)
Russell et al, 2015	CASC15	Neuroblastoma and metastatic melanoma	Tumor suppressor; inhibits proliferation and migratory	As a mediator of neural growth and differentiation to impact initiation and progression	(17)
Pan et al, 2016	GAS8-AS1	Papillary thyroid	Tumor suppressor; inhibits cancer growth	Unknown	(22)
Liu et al, 2015	SIRT1-AS	Hepatocellular	Promotes proliferation	Binds to SIRT1 mRNA at 3′UTR, masks the microRNA-29c binding site and stabilizes SIRT1 mRNA	(23)
Sánchez et al, 2014	PR-lncRNA-1	Colorectal	Tumor suppressor; inhibits cell survival and proliferation	Modulates gene expression response to DNA damage downstream of p53	(41)
Hünten et al, 2015; Kaller et al, 2017	LINC01021	Colorectal	Inhibits proliferation	A novel direct p53 target gene	(42,43)
Merry et al, 2015; Somasundaram et al, 2018	DACOR1	Colon	Growth suppressor	Changes DNA methylation patterns without affecting DNMT1 protein levels	(47,48)
Kondo et al, 2017	JHDM1D-AS1	Pancreatic	Promotes tumorigenesis	Regulates angiogenesis in response to nutrient starvation	(49)
Hu et al, 2019	LINK-A	Breast	Downregulates cancer antigenicity	Inactivation of protein kinase A pathways	(50)

lncRNAs, long non-coding RNAs; PVT1, plasmacytoma variant translocation 1; CASC15, cancer-associated susceptibility candidate 15; GAS8-AS1, GAS8 antisense RNA 1; SIRT1-AS, sirtuin 1-antisense; SIRT1, sirtuin 1; 3′UTR, 3′-untranslated region; PR-lncRNA-1, p53-regulated lncRNA-1; DACOR1, DNMT1-associated colon cancer repressed lncRNA 1; JHDM1D-AS1, JHDM1D antisense 1; LINK-A, lncRNA long intergenic non-coding RNA for kinase activation.