Table I.
Prognostic impact of PRSS1 genotype on the prognosis of patients with pancreatic ductal adenocarcinoma.
| PRSS1 genotype | |||
|---|---|---|---|
| Variable | T/C | T/T and C/C | P-value |
| Age, years (mean ± SD) | 61.5±12.7 | 59.7±10.3 | 0.253 |
| Sex, n (%) | 0.534 | ||
| Male | 36 (64.3) | 40 (58.8) | |
| Female | 20 (35.7) | 28 (41.2) | |
| Tumor size, cm (mean ± SD) | 3.9±2.6 | 3.2±1.5 | 0.027 |
| Tumor location, n (%) | 0.688 | ||
| Head | 41 (73.2) | 53 (77.9) | |
| Body and tail | 15 (26.8) | 15 (22.1) | |
| CEA, ng/ml (mean ± SD) | 7.7±15.1 | 15.9±48.7 | 0.038 |
| CA19-9, U/ml (mean ± SD) | 291.6±375.9 | 302.2±361.5 | 0.717 |
| CA125, U/ml (mean ± SD) | 50.1±89.3 | 45.7±78.7 | 0.460 |
| TNM stage, n (%) | 0.041 | ||
| I | 11 (19.6) | 19 (27.9) | |
| II | 13 (23.2) | 27 (39.7) | |
| III | 27 (48.2) | 20 (29.4) | |
| IV | 5 (8.9) | 2 (2.9) | |
| Perineural invasion, n (%) | 0.874 | ||
| Yes | 19 (33.9) | 24 (35.3) | |
| No | 37 (66.1) | 44 (64.7) | |
| Vascular invasion, n (%) | 0.442 | ||
| Yes | 43 (76.8) | 56 (82.4) | |
| No | 13 (23.2) | 12 (17.6) | |
PRSS1, serine protease 1; TNM, tumor-node-metastasis; CEA, carcinoembryonic antigen; CA, carbohydrate antigen.