Table II.

Univariate analysis of factors affecting the overall survival time in patients with pancreatic ductal adenocarcinoma.

	Univariate analysis
Variable	HR	95% CI	P-value
Sex (male vs. female)	0.785	0.510–1.208	0.271
Age	1.016	0.996–1.036	0.113
Surgery type (Whipple surgery vs. pancreatectomy)	1.626	1.042–2.537	0.032
Resection margin (yes vs. no)	1.049	0.476–2.315	0.905
Tumor size	1.155	1.038–1.285	0.008
Serum CA19-9 level	1.001	1.000–1.002	0.001
Serum CEA level	1.007	1.001–1.014	0.034
Serum CA125 level	1.001	0.999–1.004	0.194
TNM stage
I	Reference value		0.001
II vs. I	1.691	0.931- 3.072	0.085
III vs. I	2.257	1.272–4.005	0.005
IV vs. I	5.320	2.186–12.947	<0.001
Perineural invasion (yes vs. no)	1.303	0.841–2.020	0.237
Vascular invasion (yes vs. no)	1.487	0.921–2.398	0.104
PRSS1 genotype (T/C vs. C/C or T/T)	1.961	1.293–2.973	0.002

HR, hazard ratio; CEA, carcinoembryonic antigen; CA, carbohydrate antigen, PRSS1, serine protease 1 gene.