Table III.
Multivariate analysis of factors affecting the overall survival time in patients with pancreatic ductal adenocarcinoma.
| Variable | Regression coefficient | SE | HR | 95% CI | P-value |
|---|---|---|---|---|---|
| Surgery type (Whipple surgery vs. pancreatectomy) | −0.009 | 0.274 | 0.991 | 0.579–1.695 | 0.973 |
| Tumor size | 0.081 | 0.067 | 1.085 | 0.952–1.236 | 0.223 |
| Serum CA19-9 level | 0.001 | <0.001 | 1.001 | 1.000–1.002 | 0.001 |
| Serum CEA level | 0.006 | 0.005 | 1.006 | 0.996–1.016 | 0.230 |
| TNM stage | |||||
| I | Reference value | 0.110 | |||
| II vs. I | 0.613 | 0.345 | 1.847 | 0.938–3.634 | 0.076 |
| III vs. I | 0.731 | 0.339 | 2.078 | 1.068–4.041 | 0.031 |
| IV vs. I | 1.128 | 0.551 | 3.090 | 1.049–9.104 | 0.041 |
| PRSS1 genotype (T/C vs. C/C or T/T) | 0.786 | 0.249 | 2.196 | 1.347–3.580 | 0.002 |
SE, standard error; HR, hazard ratio; CEA, carcinoembryonic antigen; CA, carbohydrate antigen, PRSS1, serine protease 1 gene.