Figure 1.

Curcumin enhances the cytotoxicity of in K562/DOX cells. (A) Chemical structure of curcumin. K562 and K562/DOX cells were treated with (B) DOX (0–50 µM) and (C) with curcumin (0–32 µM) for 48 h. (D) K562/DOX and (E) K562 cells were pre-treated with curcumin (0.5, 1 and 2 µM) for 24 h, followed by incubation with various concentrations of DOX for an additional 48 h. ***P<0.001 vs. the control group (not treated with curcumin). DOX, doxorubicin; K562/DOX, DOX-resistant K562 cell line; S100A8, S100 calcium-binding protein A8.