Figure 5.

Methylation and mutation status of HOXC13 in breast cancer. (A) Methylation status of HOXC13 in breast cancer cell lines. The x-axis displays the cell line in which methylation was measured. The y-axis displays the position of the methylation data. The number before the colon is the chromosome, and the number after the colon the position. Red, orange and blue represent high, medium and low levels of methylation. The size of the bubble represents coverage. (B) Mutation status of HOXC13 in breast cancer from cBioPortal. The mutation types include nonstart, missense and truncation, and missense is shown as 1, 2, 3 and 4. The boxes in green and red represent the open reading frame. The scale shows where the mutation site is located in the sequence. Corresponding changed protein name contains M1, S242Y, X_246splice and S242Y. The data used included studies on breast cancer (29–34).