Table 2.
Results of spatial cytokine-phosphorylated protein response correlation analysis. Pearson correlation coefficients (r) and significance values (p) for associated cytokines and phosphorylation responses across all sampling locations are listed. N = 12 and any outliers driving correlations were identified and removed.
| Cytokine | Phosphoprotein | Correlation (r) | P |
|---|---|---|---|
| At fracture | |||
| MIP-1α | p-Akt | −0.8639 | 0.0013 |
| MIP-1α | p-p70S6 | −0.8297 | 0.0016 |
| MIP-1α | p-GSK-3α/β | −0.8161 | 0.0022 |
| MIP-1α | p-MEK1 | −0.6863 | 0.0197 |
| MIP-1α | p-ERK1/2 | −0.6515 | 0.0299 |
| 1-cm Away | |||
| MIP-1α | p-Akt | −0.6449 | 0.0321 |
| MIP-1α | p-GSK-3α/β | −0.5807 | 0.0477 |
| IL2 | p-p70S6 | −0.7543 | 0.0046 |
| IL2 | p-Akt | −0.7547 | 0.0073 |
| IL2 | p-IκBα | 0.6273 | 0.0388 |
| IL2 | p-GSK-3α/β | −0.5913 | 0.0429 |
| IL-1β | p-STAT3 | 0.7341 | 0.0066 |
| Uninjured leg | |||
| IL2 | p-STAT3 | 0.6633 | 0.0261 |
| IL2 | p-JNK | 0.6416 | 0.0333 |
| TNFα | p-ERK1/2 | 0.8460 | 0.0005 |
| TNFα | p-p70S6 | 0.7598 | 0.0041 |