Table I.
GO and KEGG pathway enrichment analysis of upregulated and downregulated genes.
| (A) Upregulated | ||||
|---|---|---|---|---|
| Term | Function | Gene count | % | P-value |
| GO:0000279 | M phase | 48 | 12.8 | 1.00×10−24 |
| GO:0022403 | Cell cycle phase | 53 | 14.1 | 1.30×10−24 |
| GO:0007049 | Cell cycle | 69 | 18.4 | 5.70×10−23 |
| GO:0000087 | M phase of mitotic cell cycle | 38 | 10.1 | 8.10×10−22 |
| GO:0022402 | Cell cycle process | 57 | 15.2 | 2.10×10−21 |
| GO:0005694 | Chromosome | 46 | 12.3 | 2.20×10−17 |
| GO:0044427 | Chromosomal part | 41 | 10.9 | 2.20×10−16 |
| GO:0000793 | Condensed chromosome | 23 | 6.1 | 8.10×10−14 |
| GO:0000775 | Chromosome, centromeric region | 22 | 5.9 | 3.50×10−13 |
| GO:0043228 | Non-membrane-bounded organelle | 102 | 27.2 | 1.20×10−9 |
| GO:0005524 | ATP binding | 51 | 13.6 | 3.00×10−4 |
| GO:0032559 | Adenyl ribonucleotide binding | 51 | 13.6 | 4.10×10−4 |
| GO:0030554 | Adenyl nucleotide binding | 53 | 14.1 | 4.20×10−4 |
| GO:0001883 | Purine nucleoside binding | 53 | 14.1 | 6.00×10−4 |
| GO:0001882 | Nucleoside binding | 53 | 14.1 | 7.00×10−4 |
| KEGG:hsa04110 | Cell cycle | 20 | 5.3 | 7.70×10−11 |
| KEGG:hsa04115 | p53 signaling pathway | 11 | 2.9 | 4.20×10−6 |
| KEGG:hsa03030 | DNA replication | 7 | 1.9 | 1.90×10−4 |
| KEGG:hsa00670 | One carbon pool by folate | 5 | 1.3 | 4.70×10−4 |
| KEGG:hsa04114 | Oocyte meiosis | 8 | 2.1 | 1.70×10−2 |
| (B) Downregulated | ||||
| Term | Function | Gene count | % | P-value |
| GO:0044459 | Plasma membrane part | 84 | 27.5 | 1.70×10−11 |
| GO:0005886 | Plasma membrane | 117 | 38.4 | 1.40×10−10 |
| GO:0001944 | Vasculature development | 23 | 7.5 | 2.10×10−10 |
| GO:0001568 | Blood vessel development | 22 | 7.2 | 8.40×10−10 |
| GO:0048514 | Blood vessel morphogenesis | 19 | 6.2 | 1.50×10−8 |
| GO:0007155 | Cell adhesion | 32 | 10.5 | 6.40×10−7 |
| GO:0022610 | Biological adhesion | 32 | 10.5 | 6.60×10−7 |
| GO:0003779 | Actin binding | 20 | 6.6 | 2.20×10−6 |
| GO:0008092 | Cytoskeletal protein binding | 24 | 7.9 | 1.10×10−5 |
| GO:0050431 | Transforming growth factor beta binding | 5 | 1.6 | 1.40×10−5 |
| GO:0031226 | Intrinsic to plasma membrane | 44 | 14.4 | 2.20×10−5 |
| GO:0005887 | Integral to plasma membrane | 42 | 13.8 | 6.20×10−5 |
| GO:0009986 | Cell surface | 19 | 6.2 | 8.20×10−5 |
| GO:0051015 | Actin filament binding | 7 | 2.3 | 2.40×10−4 |
| GO:0032403 | Protein complex binding | 12 | 3.9 | 4.40×10−4 |
| KEGG:hsa04270 | Vascular smooth muscle contraction | 9 | 3.0 | 1.20×10−3 |
| KEGG:hsa04514 | Cell adhesion molecules | 9 | 3.0 | 3.50×10−3 |
| KEGG:hsa05414 | Dilated cardiomyopathy | 7 | 2.3 | 7.90×10−3 |
| KEGG:hsa04530 | Tight junction | 8 | 2.6 | 1.40×10−2 |
| KEGG:hsa05410 | Hypertrophic cardiomyopathy | 6 | 2.0 | 2.20×10−2 |
GO, Gene Ontology; KEGG, Kyoto Encyclopedia of Genes and Genomes; has, homosapien.