Table II.
Functional and pathway enrichment analysis of genes in the module.
| Pathway ID | Pathway description | Gene count | False discovery rate | Nodes |
|---|---|---|---|---|
| GO.0000278 | Mitotic cell cycle | 12 | 8.58×10−12 | BLM, BUB1, CHEK1, MCM2, MCM4, MCM6, MLF1IP, ORC1, ORC6, PLK1, RFC4, TYMS |
| GO.0044772 | Mitotic cell cycle phase transition | 9 | 2.87×10−10 | CDK1, CHEK1, MCM2, MCM4, MCM6, ORC1, ORC6, PLK1, TYMS |
| GO.1903047 | Mitotic cell cycle process | 10 | 5.38×10−9 | BLM, BUB1, CHEK1, MCM2, MCM4, MCM6, ORC1, ORC6, PLK1, TYMS |
| GO.0000082 | G1/S transition of mitotic cell cycle | 7 | 1.74×10−8 | CDK1, MCM2, MCM4, MCM6, ORC1, ORC6, TYMS |
| GO.0006268 | DNA unwinding involved in DNA replication | 4 | 5.66×10−8 | MCM2, MCM4, MCM6, RAD51 |
| GO.0005524 | ATP binding | 11 | 9.36×10−8 | BLM, BUB1, CDK1, CHEK1, MCM2, MCM4, MCM6, ORC1, PLK1, RAD51, RFC4 |
| GO.0000166 | Nucleotide binding | 12 | 1.62×10−7 | BLM, BUB1, CDK1, CHEK1, MCM2, MCM4, MCM6, ORC1, PLK1, RAD51, RFC4, TYMS |
| GO.0043168 | Anion binding | 12 | 2.27×10−7 | BLM, BUB1, CDK1, CHEK1, MCM2, MCM4, MCM6, ORC1, PLK1, RAD51, RFC4, TYMS |
| GO.0003697 | Single-stranded DNA binding | 4 | 3.14×10−5 | BLM, MCM4, MCM6, RAD51 |
| GO.0005654 | Nucleoplasm | 14 | 6.79×10−10 | BLM, BUB1, CDK1, CHEK1, MCM2, MCM4, MCM6, MLF1IP, ORC1, ORC6, PLK1, RAD51, RFC4, TYMS |
| GO.0044454 | Nuclear chromosome part | 7 | 8.90×10−7 | BLM, BUB1, MCM2, ORC1, ORC6, PLK1, RAD51 |
| GO.0000228 | Nuclear chromosome | 7 | 1.45×10−6 | BLM, BUB1, CHEK1, MCM2, ORC1, ORC6, PLK1 |
| KEGG:hsa04110 | Cell cycle | 8 | 9.91×10−13 | BUB1, CHEK1, MCM2, MCM4, MCM6, ORC1, ORC6, PLK1 |
| KEGG:hsa03030 | DNA replication | 4 | 1.02×10−6 | MCM2, MCM4, MCM6, RFC4 |
GO, Gene Ontology; KEGG, Kyoto Encylopedia of Genes and Genomes; has, homosapien.