Table I.
Features of squamous cell carcinoma associated with inverted papilloma.
| Patients/sex/age | Lateral/origin site | Extent site | Main symptom | TNM stage | Surgical procedure | Surgical margin | Type | Adjuvant therapy | Recurrence | Follow up (months) | Outcome |
|---|---|---|---|---|---|---|---|---|---|---|---|
| 1/M/58 | R/MS | NC, ES, IF, AB | Cheek pain | 4 | ETR + CLO | Positive | Synchronous | IT+CRT | 1 | 20 | AWD/brain metastasis |
| 2/M/59 | L/NC | / | Nasal obstruction | 1 | ETR | Free | Synchronous | No | No | 20 | NED |
| 3/M/49 | L/NC | MS, ES, OW | Nasal obstruction | 3 | ETR + CLO | Free | Metachronous | No | 1 | 22 | NED |
| 4/M/70 | L/NC | ES | Nasal obstruction | 2 | ETR | Free | Synchronous | CRT | No | 19 | DOC/cerebral infarction |
| 5/M/64 | R/MS | NC, ES, SS, PF, IF, AB | Nasal obstruction | 4 | ETR | Positive | Synchronous | RT + CRT | 2 | 12 | DOD |
| 6/F/68 | L/NS, ES | OW | Epistaxis | 3 | LR | Free | Synchronous | RT + CRT | 4 | 123 | DOD/liver metastasis |
| 7/M/67 | L/MS | PF, IF, ES, OW | Nasal obstruction | 4 | ETR | Free | Metachronous | RT | No | 61 | NED |
| 8/M/68 | L/MS | NC, ABFST | Cheek pain | 3 | ETR | Positive | Metachronous | RT | No | 59 | NED |
| 9/F/49 | R/MS | NC, ES | Nasal obstruction | 3 | ETR + PME | Free | Synchronous | No | No | 28 | Unknown |
| 10/M/66 | R/MS | / | Nasal obstruction | 1 | ETR | Free | Metachronous | No | No | 103 | NED |
| 11/M/35 | L/MS | ES, OW | Nasal obstruction | 3 | ETR | Free | Synchronous | RT + CRT | 2 | 75 | AWD |
| 12/M/53 | L/NC | MS, ES, SS, PF, IO | Decreased vision | 4 | ETR | Positive | Synchronous | RT + CRT | 1 | 3 | DOD |
| 13/M/55 | L/MS | NC, ES, IFOW | Epiphora | 4 | ETR | Free | Metachronous | RT + CRT | 1 | 17 | DOD |
| 14/M/45 | R/ES | FS, IO ACB | Epistaxis | 4 | ETR + EI | Positive | Metachronous | RT + CRT | 1 | 14 | DOD |
| 15/M/52 | L/MS | OW | Nasal obstruction | 3 | ETR | Free | Metachronous | RT | No | 60 | NED |
| 16/F/57 | R/NC | MS | Nasal obstruction | 3 | ETR | Free | Synchronous | RT | No | 87 | Unknown |
| 17/M/61 | L/NC | ES, MS | Nasal obstruction | 3 | ETR | Free | Synchronous | CRT | No | 54 | NED |
| 18/M/68 | R/NC | ES, MS | Nasal obstruction | 3 | ETR | Free | Synchronous | RT + CRT | No | 43 | DOC/Cerebral infarction |
| 19/M56 | L/MS | NC, ES, SS, OW, LS | Epiphora | 4 | ETR | Positive | Synchronous | RT | No | 12 | Unknown |
| 20/M/63 | L/NC, ES | FS, OW | Epistaxis | 4 | ETR | Free | Metachronous | RT | 4 | 60 | NED |
| 21/M/81 | L/MS | NC, ES | Epistaxis | 3 | ETR | Free | Synchronous | RT | No | 103 | NED |
MS, maxillary sinus; NC, nasal cavity; ES, ethmoid sinus; SS, sphenoid sinus; FS, frontal sinus PF; pterygopalatine fossa; IF, infratemporal fossa; AB, alveolar bone; OW, orbital wall; FST, facial subcutaneous tissue; IO, intra-orbit; LS, Lacrimal sac; ACB, anterior cranial base; ETR, endoscopic transnasal resection; CLO, Caldwell-Luc operation; EI, external incision; PME, partial maxillary excision; LR, lateral rhinotomy; IT, immunotherapy; RT, radiotherapy; CRT, chemoradiotherapy; NED, no evidence of disease; DOD, die of disease; AWD, alive with disease; DOC, die of another cause.