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. Author manuscript; available in PMC: 2020 Dec 1.
Published in final edited form as: Neuropharmacology. 2019 Sep 25;160:107793. doi: 10.1016/j.neuropharm.2019.107793

Fig. 5. Tolerance to the antinociceptive effects of ethanol following repeated exposure.

Fig. 5.

(A) Mechanical hypersensitivity in C57BL/6J mice following 4 days of gavage using vehicle or 1.25 g/kg ethanol. BL indicates pre-surgical mechanical thresholds while Pre-Trt indicates the threshold following CCI surgery to induce neuropathy. Challenge indicates the mechanical threshold 30 min after a treatment with 1.25 g/kg ethanol by oral gavage on challenge day following repeated gavage. n = 8–10 per group. (B) Mechanical hypersensitivity in C57BL/6J mice following 10 days of gavage using vehicle or 1.25 g/kg ethanol. Data are expressed as mean ± S.E.M. of n = 8–10 per group. *p < 0.05 vs. vehicle.