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. Author manuscript; available in PMC: 2020 Dec 1.
Published in final edited form as: Neuropharmacology. 2019 Sep 25;160:107793. doi: 10.1016/j.neuropharm.2019.107793

Fig. 6. Antagonism of ethanol-induced antinociception in CCI mice assessed using mechanical sensitivity.

Fig. 6.

(A) BL indicates the threshold for animals following CCI surgery to induce neuropathy. Pre-Trt indicates the threshold for animals after CCI that have received naloxone at 2 or 4 mg/kg. Trt indicates withdrawal threshold 30 min after EtOH-induced mechanical sensitivity in CCI animals pretreated with naloxone. *P < 0.05 vs. veh + veh; #P < 0.05 vs. Veh + EtOH. n = 8/group. (B) Withdrawal threshold for male C57BL/6J mice after CCI surgery. BL indicates the baseline threshold for animals after CCI. Pre-Trt indicates threshold for animals after naltrindole (NTL) or nor-BNI. Trt indicates mechanical withdrawal threshold 30 min after EtOH administration in CCI animals pretreated with the antagonists. *P < 0.05 vs. Veh/EtOH. Data are expressed as mean ± S.E.M. of n = 8/group. Veh = Vehicle; EtOH = ethanol.