Fig. 8. Antinociceptive effects of ethanol in CCI animals assessed by CPP.
EtOH induced preference for the ethanol-paired side in CCI but not sham mice. C57BL/6J male mice conditioned with 1.25 g/kg or vehicle daily for 6 days as either sham or CCI animals. No preference was established in sham animals at doses that are antinociceptive. CCI animals conditioned with EtOH display preference for the EtOH paired chamber. Preference score is calculated as the (time spent drug side) - (time spent on veh side). *P < 0.05 vs. sham. Data are expressed as mean ± S.E.M. of n = 12 per treatment group.