Table 2.
Relative activation of signaling pathways in T cells and NK cells from blood and liver
| Pathway name | Genes in pathway (total) | Blood CD3 FC | Liver CD3 FC | Blood NK FC | Liver NK FC |
|---|---|---|---|---|---|
| Glycolysis / gluconeogenesis | 68 (100%)a | 2.8 (64%) | 2.5 (58%) | −2.7 (64%) | −2.2 (51%) |
| Cell cycle | 124 (100%) | 0.0 (84%) | 0.9 (77%) | −1.3 (89%) | 1.7 (73%) |
| Lysosome | 123 (100%) | −4.2 (89%) | −4.0 (82%) | 7.3 (88%) | 1.8 (71%) |
| NK cell‐mediated cytotoxicity | 133 (100%) | −11.7 (71%) | −3.7 (70%) | 3.6 (77%) | 2.6 (69%) |
| Oxidative phosphorylation | 133 (100%) | 7.2 (68%) | −5.0 (67%) | 4.5 (68%) | −4.3 (62%) |
| Hepatitis B | 144 (100%) | −0.2 (77%) | 1.7 (73%) | 1.6 (79%) | −1.4 (67%) |
| Th1 and Th2 cell differentiation | 92 (100%) | −5.9 (86%) | 1.5 (82%) | 1.6 (85%) | −1.0 (72%) |
| Mismatch repair | 23 (100%) | 2.3 (96%) | −0.5 (88%) | 0.8 (98%) | −1.6 (83%) |
a
The percentage of overlap with the original list of genes in that pathway to estimate the degree of representation of each pathway in every sample.
FC; fold change.