Table 4 . Multivariate analysis overall survival and breast cancer-specific survival.
Variable | Overall survival | Breast cancer-specific survival | ||
---|---|---|---|---|
Hazard ratio [95% CI] | P value | Hazard ratio [95% CI] | P value | |
Age at diagnosis, years | ||||
18–40 | Reference | Reference | ||
41–60 | 1.236 [1.012–1.509] | 0.038 | 1.277 [1.034–1.577] | 0.023 |
61–80 | 1.491 [1.217–1.825] | <0.001 | 1.479 [1.193–1.832] | <0.001 |
>80 | 2.189 [1.720–2.784] | <0.001 | 2.107 [1.628–2.727] | <0.001 |
Sex | ||||
Male | Reference | Reference | ||
Female | 1.177 [0.808–1.715] | 0.397 | 1.306 [0.855–1.996] | 0.217 |
Race | ||||
White | Reference | Reference | ||
Black | 1.246 [1.112–1.397] | <0.001 | 1.221 [1.081–1.379] | 0.001 |
Other | 0.982 [0.836–1.154] | 0.829 | 0.943 [0.792–1.123] | 0.509 |
Marital status | ||||
Single | Reference | Reference | ||
Married/domestic partner | 0.805 [0.717–0.905] | <0.001 | 0.794 [0.702–0.898] | <0.001 |
Divorced/separated/widowed | 1.048 [0.928–1.185] | 0.449 | 1.020 [0.895–1.162] | 0.764 |
Tumor site(s) | ||||
Only one site (left or right) | Reference | Reference | ||
Two or more sites | 1.584 [0.976–2.572] | 0.063 | 1.733 [1.051–2.857] | 0.031 |
Tumor grade | ||||
I | Reference | Reference | ||
II | 1.301 [1.044–1.620] | 0.019 | 1.374 [1.075–1.756] | 0.011 |
III | 1.865 [1.492–2.330] | <0.001 | 2.070 [1.615–2.652] | <0.001 |
IV | 1.635 [1.037–2.580] | 0.034 | 1.796 [1.099–2.934] | 0.019 |
Histology | ||||
Ductal | Reference | Reference | ||
Lobular | 0.913 [0.714–1.169] | 0.471 | 0.922 [0.708–1.202] | 0.55 |
Mixed ductal and lobular | 1.056 [0.860–1.298] | 0.603 | 1.058 [0.847–1.322] | 0.617 |
Mucinous | 0.765 [0.439–1.332] | 0.343 | 0.763 [0.418–1.394] | 0.379 |
Carcinoma | 1.412 [1.218–1.636] | <0.001 | 1.364 [1.165–1.598] | <0.001 |
Tumor subtype | ||||
HR+/HER2− | Reference | Reference | ||
HR+/HER2+ | 0.906 [0.786–1.045] | 0.175 | 0.914 [0.786–1.063] | 0.244 |
HR−/HER2+ | 1.272 [1.073–1.508] | 0.005 | 1.232 [1.027–1.478] | 0.025 |
Triple-negative | 2.766 [2.436–3.140] | <0.001 | 2.872 [2.510–3.285] | <0.001 |
Extrapulmonary metastatic sites to bone, brain, and liver, No. | ||||
0 | Reference | Reference | ||
1 | 1.477 [1.323–1.649] | <0.001 | 1.512 [1.344–1.702] | <0.001 |
2 | 2.429 [2.137–2.760] | <0.001 | 2.489 [2.171–2.853] | <0.001 |
All 3 | 3.833 [3.022–4.862] | <0.001 | 3.950 [3.072–5.080] | <0.001 |
Cancer-directed surgery | ||||
Performed | Reference | Reference | ||
Not performed | 1.541 [1.389–1.710] | <0.001 | 1.519 [1.360–1.697] | <0.001 |
Radiation | ||||
Yes | Reference | Reference | ||
No | 1.047 [0.949–1.154] | 0.362 | 1.047 [0.943–1.162] | 0.393 |
Chemotherapy | ||||
Yes | Reference | Reference | ||
No/unknown | 1.457 [1.313–1.618] | <0.001 | 1.420 [1.270–1.588] | <0.001 |