Table 3.

Association between SCV subtypes and occurrence of pulmonary exacerbations in univariate and multivariate analyses.

	Univariate			Multivariate			Multivariate			Multivariate
Covariatea	ORb	95% CI	p-value	OR	95% CI	p-value	OR	95% CI	p-value	OR	95% CI	p-value
SCV Culture Status
Never SCV Pos*	1			1			1			1
Ever Non-THYD SCV	1.076	(0.677–1.709)	0.76	1.037	(0.654–1.645)	0.88	1.010	(0.644–1.584)	0.97	1.008	(0.645–1.574)	0.97
Ever THYD SCV	2.808	(1.687–4.672)	0.0001	2.497	(1.513–4.121)	0.0003	2.386	(1.464–3.889)	0.0005	2.174	(1.326–3.567)	0.0021
Visit number	0.890	(0.833–0.951)	0.0006	0.898	(0.844–0.955)	0.0007	0.898	(0.843–0.955)	0.0007	0.896	(0.842–0.954)	0.0005
Age at enrollment				1.078	(1.022–1.137)	0.0060	1.093	(1.037–1.153)	0.0010	1.081	(1.025–1.140)	0.0042
Sex
Male*				1			1			1
Female				1.416	(1.021–1.965)	0.0373	1.486	(1.078–2.049)	0.0155	1.437	(1.045–1.976)	0.0258
Hispanic race
Hispanic*				1			1			1
Non-Hispanic				0.854	(0.378–1.927)	0.70	0.743	(0.334–1.649)	0.47	0.765	(0.349–1.674)	0.50
Genotype
F508 homoz*				1			1			1
F508 heteroz				1.092	(0.763–1.562)	0.63	1.033	(0.727–1.468)	0.86	1.018	(0.718–1.443)	0.92
Other				0.770	(0.438–1.353)	0.36	0.765	(0.441–1.328)	0.34	0.727	(0.420–1.258)	0.25
CFTR Modulator
No*				1			1			1
Yes				0.547	(0.280–1.067)	0.08	0.532	(0.277–1.022)	0.06	0.565	(0.296–1.075)	0.08
P. aeruginosa Cx Status
Never PA Pos*							1			1
Ever PA Pos							0.551	(0.383–0.794)	0.0014	0.519	(0.359–0.749)	0.0005
GLI FEV1pp at enrollment										0.992	(0.984–1.001)	0.10

^*Baseline category

^aSCV categories are mutually exclusive.

^bAbbreviations: Odds Ratio, OR; Confidence Interval, CI; Culture, Cx; THYD, thymidine-dependent.