Figure 4.

The effect of the SINE Alu insertions on Pfam domains. (A) The seed alignment for Pfam domain Cmc1. Conserved cysteines are marked with red arrows, the region of Pfam domain equivalent to the region replaced by the SINE Alu element insert is shown by the green arrow. It would not affect the four conserved cysteines. (B) The structure of the ADARB1 catalytic domain (PDB (70) structure: 1ZY7). The catalytic region and the phytic acid co-factor are shown with the large arrow. The SINE Alu element would be inserted into the disordered region, the start and end of which is marked by the smaller arrows and would therefore not interact directly with the catalytic domain of ABARB1.