Table 1.
Gene mutations associated with pancreatic adenocarcinoma [2].
| Types of Mutation | Gene Symbol | Gene Description | Entrez Gene ID | Ensembl Gene ID |
|---|---|---|---|---|
| Somatic | AKT2 | AKT serine/threonine kinase 2 | 208 | ENSG00000105221 |
| ARID1A | AT-rich interaction domain 1A | 8289 | ENSG00000117713 | |
| BRAF | B-Raf proto-oncogene, serine/threonine kinase | 673 | ENSG00000157764 | |
| CCSER1/FAM190A | Coiled-coil serine rich protein 1 | 401,145 | ENSG00000184305 | |
| CDKN2A | Cyclin dependent kinase inhibitor 2A | 1029 | ENSG00000147889 | |
| EP300 | E1A binding protein p300 | 2033 | ENSG00000100393 | |
| KMT2C/MLL3 | Lysine methyltransferase 2C | 58,508 | ENSG00000055609 | |
| KRAS | KRAS proto-oncogene, GTPase | 3845 | ENSG00000133703 | |
| MYB | MYB proto-oncogene, transcription factor | 4602 | ENSG00000118513 | |
| NCOA3/AIB1 | Nuclear receptor coactivator 3 | 8202 | ENSG00000124151 | |
| SMAD4 | SMAD family member 4 | 4089 | ENSG00000141646 | |
| TGFBR2 | Transforming growth factor beta receptor 2 | 7048 | ENSG00000163513 | |
| TP53 | Tumor protein p53 | 7157 | ENSG00000141510 | |
| USP9X | Ubiquitin specific peptidase 9, X-linked | 8239 | ENSG00000124486 | |
| Germline | ATM | ATM serine/threonine kinase | 472 | ENSG00000149311 |
| BRCA2 | BRCA2, DNA repair associated | 675 | ENSG00000139618 | |
| CDKN2A | Cyclin dependent kinase inhibitor 2A | 1029 | ENSG00000147889 | |
| PALB2 | Partner and localizer of BRCA2 | 79,728 | ENSG00000083093 | |
| PRSS1 | Protease, serine 1 | 5644 | ENSG00000204983 | |
| STK11 | Serine/threonine kinase 11 | 6794 | ENSG00000118046 |