Table 2.
Functional enrichment analysis of common somatic genes mutated in pancreatic adenocarcinoma.
| Cluster No. (E Score) | Database | Functional Term | Fold Enrichment | p Value | Benjamini |
|---|---|---|---|---|---|
| Cluster 1 (3.12) | UP_KEYWORDS | Acetylation | 4.723 | 0.0000028 | 0.0002505 |
| KEGG_PATHWAY | Cell cycle | 20.264 | 0.0006173 | 0.0033905 | |
| UP_KEYWORDS | Transcription | 4.904 | 0.0002617 | 0.0046472 | |
| UP_KEYWORDS | Transcription regulation | 5.043 | 0.0002192 | 0.0048656 | |
| GOTERM_BP_DIRECT | Positive regulation of transcription, DNA-templated | 15.049 | 0.0000176 | 0.0066071 | |
| BIOCARTA | First Multivalent Nuclear Factor | 28.889 | 0.0001714 | 0.0068348 | |
| UP_KEYWORDS | Nucleus | 2.803 | 0.0011438 | 0.0101343 | |
| UP_KEYWORDS | Phosphoprotein | 2.139 | 0.0013327 | 0.0107323 | |
| GOTERM_CC_DIRECT | Nuclear chromatin | 29.054 | 0.0002398 | 0.0112081 | |
| GOTERM_CC_DIRECT | Nucleoplasm | 4.028 | 0.0007497 | 0.0174706 | |
| GOTERM_CC_DIRECT | Nucleus | 2.589 | 0.0015626 | 0.0242026 | |
| GOTERM_MF_DIRECT | DNA binding | 5.430 | 0.0005138 | 0.0263695 | |
| Cluster 2 (2.95) | KEGG_PATHWAY | FoxO signaling pathway | 28.128 | 0.0000006 | 0.0000098 |
| KEGG_PATHWAY | Adherens junction | 26.543 | 0.0044414 | 0.0168064 | |
| KEGG_PATHWAY | TGF-beta signaling pathway | 22.435 | 0.0061682 | 0.0224314 | |
| Cluster 3 (2.86) | KEGG_PATHWAY | Chronic myeloid leukemia | 61.073 | 0.0000000 | 0.0000000 |
| KEGG_PATHWAY | Pancreatic cancer | 67.650 | 0.0000000 | 0.0000000 | |
| KEGG_PATHWAY | Colorectal cancer | 60.792 | 0.0000000 | 0.0000003 | |
| KEGG_PATHWAY | HTLV-I infection | 19.631 | 0.0000000 | 0.0000003 | |
| KEGG_PATHWAY | Pathways in cancer | 12.787 | 0.0000002 | 0.0000037 | |
| KEGG_PATHWAY | FoxO signaling pathway | 28.128 | 0.0000006 | 0.0000098 | |
| KEGG_PATHWAY | Non-small cell lung cancer | 56.088 | 0.0000008 | 0.0000111 | |
| KEGG_PATHWAY | Glioma | 48.322 | 0.0000014 | 0.0000178 | |
| KEGG_PATHWAY | Melanoma | 44.238 | 0.0000021 | 0.0000226 | |
| KEGG_PATHWAY | Prostate cancer | 35.692 | 0.0000049 | 0.0000482 | |
| KEGG_PATHWAY | Thyroid hormone signaling pathway | 27.552 | 0.0000137 | 0.0001230 | |
| KEGG_PATHWAY | Bladder cancer | 61.286 | 0.0000226 | 0.0001865 | |
| KEGG_PATHWAY | Hepatitis B | 21.661 | 0.0000354 | 0.0002697 | |
| KEGG_PATHWAY | Endometrial cancer | 48.322 | 0.0000465 | 0.0003286 | |
| KEGG_PATHWAY | Renal cell carcinoma | 38.657 | 0.0000910 | 0.0006002 | |
| UP_KEYWORDS | Disease mutation | 5.188 | 0.0000396 | 0.0011754 | |
| KEGG_PATHWAY | MAPK signaling pathway | 12.317 | 0.0003191 | 0.0019727 | |
| KEGG_PATHWAY | Neurotrophin signaling pathway | 20.939 | 0.0005607 | 0.0032611 | |
| KEGG_PATHWAY | Hepatitis C | 18.893 | 0.0007577 | 0.0037452 | |
| KEGG_PATHWAY | Thyroid cancer | 64.984 | 0.0007496 | 0.0038995 | |
| UP_KEYWORDS | Proto-oncogene | 24.916 | 0.0003911 | 0.0043423 | |
| KEGG_PATHWAY | Proteoglycans in cancer | 12.564 | 0.0024661 | 0.0115730 | |
| KEGG_PATHWAY | Viral carcinogenesis | 12.257 | 0.0026465 | 0.0118544 | |
| KEGG_PATHWAY | Acute myeloid leukemia | 33.653 | 0.0027845 | 0.0119306 | |
| KEGG_PATHWAY | Central carbon metabolism in cancer | 29.446 | 0.0036227 | 0.0148594 | |
| KEGG_PATHWAY | Long-term potentiation | 28.554 | 0.0038486 | 0.0151538 | |
| UP_SEQ_FEATURE | Mutagenesis site | 5.233 | 0.0001733 | 0.0202413 | |
| KEGG_PATHWAY | MicroRNAs in cancer | 8.817 | 0.0067131 | 0.0227320 | |
| KEGG_PATHWAY | ErbB signaling pathway | 21.661 | 0.0066041 | 0.0231553 | |
| KEGG_PATHWAY | Progesterone-mediated oocyte maturation | 21.661 | 0.0066041 | 0.0231553 | |
| GOTERM_CC_DIRECT | Cytosol | 3.383 | 0.0021984 | 0.0255285 | |
| UP_KEYWORDS | Isopeptide bond | 6.493 | 0.0043625 | 0.0274111 | |
| UP_KEYWORDS | Apoptosis | 10.971 | 0.0041342 | 0.0279639 | |
| KEGG_PATHWAY | PI3K-Akt signaling pathway | 7.283 | 0.0113878 | 0.0370899 | |
| KEGG_PATHWAY | Sphingolipid signaling pathway | 15.705 | 0.0122869 | 0.0387127 | |
| UP_KEYWORDS | Kinase | 8.000 | 0.0099232 | 0.0434085 | |
| KEGG_PATHWAY | Signaling pathways regulating pluripotency of stem cells | 13.461 | 0.0164870 | 0.0486500 | |
| KEGG_PATHWAY | Insulin signaling pathway | 13.656 | 0.0160424 | 0.0488026 | |
| Cluster 4 (2.60) | KEGG_PATHWAY | Cell cycle | 20.264 | 0.0006173 | 0.0033905 |
| KEGG_PATHWAY | Viral carcinogenesis | 12.257 | 0.0026465 | 0.0118544 | |
| KEGG_PATHWAY | MicroRNAs in cancer | 8.817 | 0.0067131 | 0.0227320 | |
| GOTERM_MF_DIRECT | p53 binding | 58.144 | 0.0009983 | 0.0340310 | |
| GOTERM_BP_DIRECT | Apoptotic process | 11.391 | 0.0005128 | 0.0470735 | |
| Cluster 5 (2.58) | KEGG_PATHWAY | Hepatitis B | 21.661 | 0.0000354 | 0.0002697 |
| KEGG_PATHWAY | Cell cycle | 20.264 | 0.0006173 | 0.0033905 | |
| UP_KEYWORDS | Ubl conjugation | 6.035 | 0.0003300 | 0.0048835 | |
| GOTERM_BP_DIRECT | Negative regulation of transcription from RNA polymerase II promoter | 10.764 | 0.0000880 | 0.0164117 | |
| UP_KEYWORDS | Isopeptide bond | 6.493 | 0.0043625 | 0.0274111 | |
| GOTERM_BP_DIRECT | Positive regulation of transcription from RNA polymerase II promoter | 7.900 | 0.0003776 | 0.0462357 | |
| KEGG_PATHWAY | Wnt signaling pathway | 13.656 | 0.0160424 | 0.0488026 | |
| Cluster 6 (1.94) | UP_KEYWORDS | Acyltransferase | 25.791 | 0.0050407 | 0.0295385 |
Functional enrichment analysis was performed with DAVID Bioinformatics Resources 6.8 using high stringency. Depicted are the functional clusters, with their enrichment scores (E scores), comprised of statistically significant terms (p < 0.05).