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. Author manuscript; available in PMC: 2019 Dec 20.
Published in final edited form as: Epigenomes. 2018 Sep 2;2(3):15. doi: 10.3390/epigenomes2030015

Table 2.

Functional enrichment analysis of common somatic genes mutated in pancreatic adenocarcinoma.

Cluster No. (E Score) Database Functional Term Fold Enrichment p Value Benjamini
Cluster 1 (3.12) UP_KEYWORDS Acetylation 4.723 0.0000028 0.0002505
KEGG_PATHWAY Cell cycle 20.264 0.0006173 0.0033905
UP_KEYWORDS Transcription 4.904 0.0002617 0.0046472
UP_KEYWORDS Transcription regulation 5.043 0.0002192 0.0048656
GOTERM_BP_DIRECT Positive regulation of transcription, DNA-templated 15.049 0.0000176 0.0066071
BIOCARTA First Multivalent Nuclear Factor 28.889 0.0001714 0.0068348
UP_KEYWORDS Nucleus 2.803 0.0011438 0.0101343
UP_KEYWORDS Phosphoprotein 2.139 0.0013327 0.0107323
GOTERM_CC_DIRECT Nuclear chromatin 29.054 0.0002398 0.0112081
GOTERM_CC_DIRECT Nucleoplasm 4.028 0.0007497 0.0174706
GOTERM_CC_DIRECT Nucleus 2.589 0.0015626 0.0242026
GOTERM_MF_DIRECT DNA binding 5.430 0.0005138 0.0263695
Cluster 2 (2.95) KEGG_PATHWAY FoxO signaling pathway 28.128 0.0000006 0.0000098
KEGG_PATHWAY Adherens junction 26.543 0.0044414 0.0168064
KEGG_PATHWAY TGF-beta signaling pathway 22.435 0.0061682 0.0224314
Cluster 3 (2.86) KEGG_PATHWAY Chronic myeloid leukemia 61.073 0.0000000 0.0000000
KEGG_PATHWAY Pancreatic cancer 67.650 0.0000000 0.0000000
KEGG_PATHWAY Colorectal cancer 60.792 0.0000000 0.0000003
KEGG_PATHWAY HTLV-I infection 19.631 0.0000000 0.0000003
KEGG_PATHWAY Pathways in cancer 12.787 0.0000002 0.0000037
KEGG_PATHWAY FoxO signaling pathway 28.128 0.0000006 0.0000098
KEGG_PATHWAY Non-small cell lung cancer 56.088 0.0000008 0.0000111
KEGG_PATHWAY Glioma 48.322 0.0000014 0.0000178
KEGG_PATHWAY Melanoma 44.238 0.0000021 0.0000226
KEGG_PATHWAY Prostate cancer 35.692 0.0000049 0.0000482
KEGG_PATHWAY Thyroid hormone signaling pathway 27.552 0.0000137 0.0001230
KEGG_PATHWAY Bladder cancer 61.286 0.0000226 0.0001865
KEGG_PATHWAY Hepatitis B 21.661 0.0000354 0.0002697
KEGG_PATHWAY Endometrial cancer 48.322 0.0000465 0.0003286
KEGG_PATHWAY Renal cell carcinoma 38.657 0.0000910 0.0006002
UP_KEYWORDS Disease mutation 5.188 0.0000396 0.0011754
KEGG_PATHWAY MAPK signaling pathway 12.317 0.0003191 0.0019727
KEGG_PATHWAY Neurotrophin signaling pathway 20.939 0.0005607 0.0032611
KEGG_PATHWAY Hepatitis C 18.893 0.0007577 0.0037452
KEGG_PATHWAY Thyroid cancer 64.984 0.0007496 0.0038995
UP_KEYWORDS Proto-oncogene 24.916 0.0003911 0.0043423
KEGG_PATHWAY Proteoglycans in cancer 12.564 0.0024661 0.0115730
KEGG_PATHWAY Viral carcinogenesis 12.257 0.0026465 0.0118544
KEGG_PATHWAY Acute myeloid leukemia 33.653 0.0027845 0.0119306
KEGG_PATHWAY Central carbon metabolism in cancer 29.446 0.0036227 0.0148594
KEGG_PATHWAY Long-term potentiation 28.554 0.0038486 0.0151538
UP_SEQ_FEATURE Mutagenesis site 5.233 0.0001733 0.0202413
KEGG_PATHWAY MicroRNAs in cancer 8.817 0.0067131 0.0227320
KEGG_PATHWAY ErbB signaling pathway 21.661 0.0066041 0.0231553
KEGG_PATHWAY Progesterone-mediated oocyte maturation 21.661 0.0066041 0.0231553
GOTERM_CC_DIRECT Cytosol 3.383 0.0021984 0.0255285
UP_KEYWORDS Isopeptide bond 6.493 0.0043625 0.0274111
UP_KEYWORDS Apoptosis 10.971 0.0041342 0.0279639
KEGG_PATHWAY PI3K-Akt signaling pathway 7.283 0.0113878 0.0370899
KEGG_PATHWAY Sphingolipid signaling pathway 15.705 0.0122869 0.0387127
UP_KEYWORDS Kinase 8.000 0.0099232 0.0434085
KEGG_PATHWAY Signaling pathways regulating pluripotency of stem cells 13.461 0.0164870 0.0486500
KEGG_PATHWAY Insulin signaling pathway 13.656 0.0160424 0.0488026
Cluster 4 (2.60) KEGG_PATHWAY Cell cycle 20.264 0.0006173 0.0033905
KEGG_PATHWAY Viral carcinogenesis 12.257 0.0026465 0.0118544
KEGG_PATHWAY MicroRNAs in cancer 8.817 0.0067131 0.0227320
GOTERM_MF_DIRECT p53 binding 58.144 0.0009983 0.0340310
GOTERM_BP_DIRECT Apoptotic process 11.391 0.0005128 0.0470735
Cluster 5 (2.58) KEGG_PATHWAY Hepatitis B 21.661 0.0000354 0.0002697
KEGG_PATHWAY Cell cycle 20.264 0.0006173 0.0033905
UP_KEYWORDS Ubl conjugation 6.035 0.0003300 0.0048835
GOTERM_BP_DIRECT Negative regulation of transcription from RNA polymerase II promoter 10.764 0.0000880 0.0164117
UP_KEYWORDS Isopeptide bond 6.493 0.0043625 0.0274111
GOTERM_BP_DIRECT Positive regulation of transcription from RNA polymerase II promoter 7.900 0.0003776 0.0462357
KEGG_PATHWAY Wnt signaling pathway 13.656 0.0160424 0.0488026
Cluster 6 (1.94) UP_KEYWORDS Acyltransferase 25.791 0.0050407 0.0295385

Functional enrichment analysis was performed with DAVID Bioinformatics Resources 6.8 using high stringency. Depicted are the functional clusters, with their enrichment scores (E scores), comprised of statistically significant terms (p < 0.05).