. Author manuscript; available in PMC: 2019 Dec 20.

Published in final edited form as: Epigenomes. 2018 Sep 2;2(3):15. doi: 10.3390/epigenomes2030015

Table 3.

Functional enrichment analysis of germline genes mutated in pancreatic adenocarcinoma.

Cluster No. (E Score)	Database	Functional Term	Fold Enrichment	p Value	Benjamini
Cluster 1 (4.25)	GOTERM_BP_DIRECT	Strand displacement	322.923	0.0000230	0.0038316
	GOTERM_BP_DIRECT	DNA synthesis involved in DNA repair	239.886	0.0000420	0.0035042
	GOTERM_BP_DIRECT	Double-strand break repair via homologous recombination	113.459	0.0001900	0.0105193
Cluster 2 (2.74)	UP_KEYWORDS	Tumor suppressor	96.897	0.0000000	0.0000015
	GOTERM_CC_DIRECT	Nucleoplasm	5.455	0.0023864	0.0557288
Cluster 3 (1.76)	GOTERM_BP_DIRECT	Cell cycle arrest	59.546	0.0006886	0.0283490
Cluster 4 (1.72)	UP_KEYWORDS	Cell cycle	21.109	0.0002990	0.0056659

Functional enrichment analysis was performed with DAVID Bioinformatics Resources 6.8 using high stringency. Depicted are the functional clusters, with their enrichment scores (E scores), comprised of statistically significant terms (p < 0.05).