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. 2019 Dec 16;12:11057–11068. doi: 10.2147/OTT.S228199

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© 2019 Cheng et al.

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The expression of drug resistance genes including MRP1, GST-π and ABCB1 was decreased in parental and DDP-resistant MG63 cells transfected with shRNA- NCK1-AS1 or control shRNA. The mRNA expression of MRP1, GST-π and ABCB1 in MG63 (A) and MG63-cis (B) cells was detected by qRT-PCR. The protein level of MRP1, GST-π and ABCB1 was determined by Western blots in MG63 (C) and MG63-cis (D) cells. The data are shown as the means ± SD. **P < 0.01, ***P < 0.001 vs. Untreated cells; ^##P < 0.01, ^###P < 0.001 vs. Control shRNA group.