Table 1.

Univariate and multivariate linear regression models for heart rate variability measure (rMSSD) in women with PCOS

Variable	Univariate regression analysis				Multivariate model* (B=4.075, R2=0.101)
	B	95% CI for B	P value	R2	B	95% CI for B	P value
PCOS	NA	NA	NA	NA	−0.087	−0.190 to 0.016	0.099
BMI 14 years	−0.011	−0.022 to 0.000	0.057	0.002
BMI 31 years	−0.022	−0.028 to −0.016	<0.001	0.022
BMI 46 years	−0.028	−0.033 to −0.023	<0.001	0.055	−0.007	−0.016 to 0.002	0.140
Waist circumference	−0.012	−0.014 to −0.010	<0.001	0.061
Systolic BP	−0.007	−0.009 to −0.005	<0.001	0.032
Diastolic BP	−0.015	−0.017 to −0.013	<0.001	0.066
Mean arterial pressure	−0.012	−0.014 to −0.010	<0.001	0.054	−0.007	−0.011 to −0.004	<0.001
Testosterone	0.042	−0.010 to 0.093	0.113	0.001
SHBG	0.001	0.001 to 0.002	<0.001	0.005
FAI	−0.121	−0.199 to −0.042	0.003	0.003	0.059	−0.055 to –0.173	0.309
Glucose	−0.121	−0.153 to −0.089	<0.001	0.023
Insulin	−0.014	−0.018 to −0.011	<0.001	0.027
HOMA-IR	−0.492	−0.585 to −0.399	<0.001	0.049	−0.256	−0.420 to −0.092	0.002
Total cholesterol	−0.067	−0.096 to −0.038	<0.001	0.009
High-density lipoprotein	0.138	0.076 to 0.201	<0.001	0.008
Low-density lipoprotein	−0.086	−0.114 to −0.058	<0.001	0.015
Triglycerides	−0.243	−0.285 to −0.200	<0.001	0.050	−0.341	−0.558 to −0.123	0.002
High-sensitive CRP	−0.071	−0.084 to −0.057	<0.001	0.034
Anxiety (HSCL-25)	−0.195	−0.274 to −0.117	<0.001	0.010

*The multivariate model included PCOS, BMI, mean arterial pressure, FAI, HOMA-IR and triglycerides as explanatory variables. B, unstandardized coefficient from linear regression analysis.

BMI, body mass index; BP, blood pressure; CRP, C-reactive protein; FAI, free androgen index; HOMA-IR, homeostasis model assessment−insulin resistance; NA, not applicable; PCOS, polycystic ovary syndrome; rMSSD, the square root of the mean squared differences of successive normal-to-normal RR intervals (RRi); SHBG, sex hormone binding globulin.