Skip to main content
. Author manuscript; available in PMC: 2020 Jun 11.
Published in final edited form as: Nature. 2019 Dec 11;576(7787):487–491. doi: 10.1038/s41586-019-1825-8

Extended Data Fig. 9. DNA methylation and chromatin accessibility dynamics of E7.5 lineage-specific enhancers and transcription factor motifs across development.

Extended Data Fig. 9

a, Box plots showing the distribution of DNA methylation (top) or chromatin accessibility (bottom) levels of E7.5 lineage-defining enhancers, across stages and cell types. Box plots show median levels and the first and third quartile, whiskers show 1.5x the interquartile range. The dashed lines represent the global background levels of DNA methylation at E7.5 (see Extended Data Fig. 3). b, Box plots showing the distribution of chromatin accessibility levels (scaled to the genome-wide background) for 200bp windows around transcription factor motifs associated with commitment to ectoderm (top), endoderm (middle) and mesoderm (bottom). Box plots show median levels and the first and third quartile, whiskers show 1.5x the interquartile range.