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. 2019 Dec 17;10(66):7043–7057. doi: 10.18632/oncotarget.27355

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Copyright: Tang et al.

This is an open-access article distributed under the terms of the Creative Commons Attribution License 3.0 (CC BY 3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

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Shows the effect of IGFBP-2 silencing in RT4 cells on (A) total cell number (B) cell death (C & D) invasion (image shows invaded cells with the nuclei stained with DAPI (in blue); X 10 magification) and graph indicates the mean change in number of invaded cells (E) colony formation; images of cells on day 1 and of colonies on day 21; x 10 magnification. (F&G) graphs represent the change in colony count and fold change of the average colony size respectively. (H) EMT markers, E- and N-cadherin and the graph shows the mean optical density change in E-cadherin. Inserts in A, C, E & H show a Western blot indicating effective IGFBP-2 silencing. Graphs show the mean and SEM of data from 3 separate experiments each performed in triplicate. Data were analysed with SPSS 12.0.1 for Windows using one-way ANOVA followed by least significant difference (LSD) post-hoc test. A statistically significant difference was present at p<0.05. NS= non-silencing control, KD= knockdown with siRNA.