Figure 2. Warfarin treatment decrease lung tumor in urethane model and Kras spontaneous mouse tumor model of lung tumorigenesis.

(A) Pre-malignant atypical adenomatous hyperplasia (AAH) lesions number in lung sections from WT and IKKβ^ΔMye mice treated with or without warfarin in drinking water (250 mg/ml) for 6 weeks after urethane injection. Representative H&E staining of lungs isolated from WT and IKKβ^ΔMye mice after warfarin treatment showing lung tumors. (B) Blood clotting time in mice treated with warfarin. (C) Surface tumor number and number of cells in BAL at 4 months after urethane injection with or without warfarin treatment. (D) Lung tumors and number of cells in BAL from LSL-K-Ras^G12D mice that received bone marrow transplantation from WT or IKKβ^ΔMye mice. Lungs were harvested at 8 weeks after intratracheal instillation of Ad-Cre. Mean ± SEM, n=10 mice per group, ^*p<0.05. Scale bars indicate 100 um.