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. 2019 Dec 17;10(66):7031–7042. doi: 10.18632/oncotarget.27345

Figure 3. Reduced lung tumorigenesis in MerTK deficient mice.

Figure 3

(A) Expression of MerTK in normal airway epithelium and pulmonary macrophages (arrows) from WT mice. (B) Expression of MerTK in lung tumors from mice at 4 months after urethane injection. (C) Lung surface tumors at 4 months after urethane injection in WT and MerTK deficient mice. n=5 mice/group. (D) Representative H&E and CD31 immunostaining of lung tumors from WT and MerTK-KO mice (E) Identification and quantification of macrophages by F4/80 immunostaining, neutrophils by MPO immunostaining, T cells by CD3 immunostaining, and cell proliferation by PCNA immunofluorescence in lung tumors of WT and MerTK-KO mice. Cells were counted in tumors on 10 slides per lung from 5 mice/group. *p<0.05. Scale bars indicate 100 um.