Figure 4. Hierarchical clustering and concordance analysis of liquid and solid biopsy cells.
(A) Clustering and heatmap for patient CRC009 with 8 clusters defined by 3rd level branching. The color bar represents tissue type. Pearson r correlation coefficients based on profiles of average scaled values of all features is displayed next to the heading. (B) Dendrograms with color bars and correlation coefficients for the other 9 patients. (C) Metacluster heatmap based on average values of patient-specific clusters. Four main clusters defined by 2nd level branching with subclusters, are shown. The color bar represents the 10 patients. The main descriptor(s) of each feature cluster is shown on top of the individual feature annotations in A and C.