Table 1. Overall population with histological sample: trans-thoracic biopsy specimens (84) + bronchial biopsy (11).

Total 95 histology samples
Age
Mean ± SD	72.6 ± 8.7
range	48–88
Gender M/F	62/33
Histotype
Squamous	17 (17.8%)
large cell	7 (7.3%)
undifferentiated	3 (3.1%)
Adenocarcinoma	68 (71.5%)
PS ECOG 1	75 (78.9%)
COPD	70 (73.6%)
Bone Metastases + Visceral Metastases	40 (42.1%)
Visceral Metastases	55 (57.8%)
Smoking status
former smoker	71 (74.7%)
current smokers	14 (15.0%)
non smokers	10 (10.5%)
mean pack year smoking	35.7 ± 12.5
Main Comorbidities: hypertension	45 (30.8%)