Table-1.
Score | Description |
---|---|
0 (−) | Normal–no hepatocytes necrosis |
1 (+) | Minimal–mild Focal, limited to centrilobular region Less than ¼ of affected lobules are necrotic |
2 (++) | Mild-moderate Focal and multifocal Central to midzonal lobular region ½ affected lobules are necrotic |
3 (+++) | Moderate to severe Multifocal (centrilobular-portal region) ¾>X>½ affected lobules are necrotic |
4 (++++) | Severe Multifocal X>¾ affected lobules are necrotic |
5 (+++++) | Severe (whole lobules) Hepatocytes loss from central vein to portal area extend to adjacent lobules |
AILI=Acetaminophen-induced liver injury