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. 2019 Nov 4;12(11):1682–1688. doi: 10.14202/vetworld.2019.1682-1688

Table-1.

AILI scores with descriptions on histopathological changes in liver cells that range from 0 (normal hepatocytes) to 5 (severe hepatocytes loss).

Score Description
0 (−) Normal–no hepatocytes necrosis
1 (+) Minimal–mild
Focal, limited to centrilobular region
Less than ¼ of affected lobules are necrotic
2 (++) Mild-moderate
Focal and multifocal
Central to midzonal lobular region ½ affected lobules are necrotic
3 (+++) Moderate to severe
Multifocal (centrilobular-portal region) ¾>X>½ affected lobules are necrotic
4 (++++) Severe
Multifocal X>¾ affected lobules are necrotic
5 (+++++) Severe (whole lobules)
Hepatocytes loss from central vein to portal area extend to adjacent lobules

AILI=Acetaminophen-induced liver injury