Fig. 6.

Protective, rebound effect on the Fractional Shortening inmdxmice between 30 and 90 days after systemic-intraosseous DEC (MB^wt/MB^mdxDEC and MB^wt/MSC^mdx) transplant confirmed by Echocardiography. a Fractional Shortening in mdx vehicle control and mdx mice systemically treated with not-fused (MB^wt + MB^mdx and MB^wt + MSC^mdx) controls and MB^wt/MB^mdx and MB^wt/MSC^mdx DEC lines (n > 3). FS values revealed an increase between day 30 and day 90 after DEC transplant for both DEC lines, the MB^wt/MB^mdx (day 30–27.35% ± 8.95; day 90–30.16% ± 2.22%) and MB^wt/MSC^mdx (day 30–31.48% ± 9.35%; day 90–37.14% ± 3.56%), while a continued drop was observed in the vehicle injected mdx controls (day 30–54.90% ± 28.00%; day 90–24.55% ± 1.91%) b Fractional Shortening in mdx mice at day 90 after intraosseous DEC (MB^wt/MB^mdx DEC and MB^wt/MSC^mdx) transplant showed significant increase in DEC injected mice when compared to vehicle injected mdx controls. FS values significantly increased for both, the MB^wt/MB^mdx (30.16% ± 2.22%, p = 0.025) and MB^wt/MSC^mdx (37.14% ± 3.56%, p = 0.045) DEC injected mdx mice compared to the vehicle injected controls (24.55% ± 1.91%)