Table 2.
Echocardiographic assessment of functional cardiac parameters at day 0 and in response to DEC therapy at 30 and 90 days after systemic DEC transplant in mdx mice
| Experimental group/ Timepoint | Functional Parameters | ||||
|---|---|---|---|---|---|
| HR (bpm) | SV (μl) | EF (%) | FS (%) | CO ml/min | |
| Day 0 | |||||
| Vehicle (n = 3) | 423.98 ± 76.08 | 31.43 ± 7.08 | 77.65 ± 4.29 | 45.17 ± 3.69 | 12.97 ± 0.43 |
| MBwt + MSCmdx (n = 3) | 416.95 ± 38.53 | 23.32 ± 1.16 | 73.32 ± 7.24 | 44.36 ± 4.10 | 8.80 ± 0.34 |
| MBwt/MBmdx (n = 4) | 408.79 ± 89.98 | 29.83 ± 10.39 | 69.46 ± 9.99 | 38.45 ± 7.55 | 11.56 ± 2.36 |
| MBwt/MSCmdx (n = 3) | 396.24 ± 54.83 | 12.76 ± 14.28 | 76.27 ± 10.46 | 58.44 ± 14.57 | 5.66 ± 6.26 |
| Day 30 | |||||
| Vehicle (n = 3) | 402.97 ± 58.45 | 15.13 ± 6.34 | 67.08 ± 12.00 | 54.90 ± 27.99 | 6.46 ± 3.44 |
| MBwt + MBmdx (n = 3) | 437.64 ± 26.37 | 15.99 ± 0.76 | 60.26 ± 2.63 | 34.26 ± 1.85 | 7.36 ± 0.35 |
| MBwt + MSCmdx (n = 3) | 475.70 ± 28.7 | 17.38 ± 0.83 | 65.32 ± 3.15 | 33.87 ± 1.78 | 8.00 ± 0.39 |
| MBwt/MBmdx (n = 4) | 489.75 ± 20.50 | 22.73 ± 4.60 | 53.51 ± 14.53 | 27.35 ± 8.95 | 11.88 ± 2.59 |
| MBwt/MSCmdx (n = 3) | 372.54 ± 12.40 | 8.00 ± 6.18 | 61.40 ± 15.01 | 31.48 ± 9.35 | 6.62 ± 3.17 |
| Day 90 | |||||
| Vehicle (n = 3) | 493.50 ± 36.00 | 22.28 ± 7.94 | 49.98 ± 3.82 | 24.55 ± 1.91 | 8.20 ± 0.61 |
| MBwt + MBmdx (n = 3) | 446.19 ± 16.06 | 19.66 ± 4.26 | 50.46 ± 2.08 | 29.35 ± 1.52 | 9.69 ± 2.47 |
| MBwt + MSCmdx (n = 3) | 490.32 ± 17.65 | 21.61 ± 4.70 | 55.45 ± 2.29 | 33.99 ± 3.73 | 10.65 ± 2.72 |
| MBwt/MBmdx (n = 4) | 511.16 ± 35.85 | 19.22 ± 3.90 | 59.07 ± 3.59† | 30.16 ± 2.22† | 9.80 ± 1.92 |
| MBwt/MSCmdx (n = 3) | 469.20 ± 10.97 | 23.45 ± 7.96 | 70.39 ± 5.80†‡ | 37.14 ± 3.56† | 10.91 ± 3.48 |
SV = stroke volume, HR = heart rate, EF = ejection fraction, FS = fractional shortening, CO = cardiac output; All values expressed as mean ± standard deviation; † Significant increase (p < 0.05) compared to vehicle group; ‡ Significant increase (p < 0.05) compared to corresponding non-fused cell group; †‡ Significant increase (p < 0.05) compared to vehicle and corresponding non-fused cell group