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. 2019 Oct 25;41(6):711–725. doi: 10.1007/s11357-019-00102-1

Fig. 4.

Fig. 4

Treatment with resveratrol encapsulated in novel fusogenic liposomes rescues endothelium-dependent neurovascular coupling responses in aged mice. Panel A: Representative pseudocolour laser speckle flowmetry maps of baseline CBF (upper row) and CBF changes in the whisker barrel field (circle) relative to baseline (differential images are shown in the bottom row) during contralateral whisker stimulation (30 s, 5 Hz) in untreated young (3 month old) and aged (24 month old) mice and aged mice treated with fusogenic liposomes (FL) and resveratrol containing fusogenic liposomes (FL-RSV), before and after administration of the NO synthase inhibitor L-NAME. Color bar represents CBF as percent change from baseline. Panel B shows the time-course of CBF changes in the whisker barrel cortex (see circle in Panel A) after the start of contralateral whisker stimulation (horizontal bars). Summary data are shown in panel C. Data are mean ± S.E.M. (n = 6–8 in each group), *P < 0.05 vs. Young; #P < 0.05 vs. Aged+FL-RSV. (one-way ANOVA with post-hoc Tukey’s tests)