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. 2019 Dec 20;9:19560. doi: 10.1038/s41598-019-56163-x

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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In vitro assessment of ^99mTc-HYNIC-D-P8RI in human plasma (a,b). (a) Percentage of human plasma protein binding over 4 h (mean ± SD) evaluated by size exclusion chromatography. Control (grey bar) refers to the same experiment performed in PBS instead of human plasma. (b) Percentage of intact ^99mTc-HYNIC-D-P8RI in human plasma over 4 h, referred as RCP and assessed by RP-HPLC. (c) Biodistribution (%ID/g, n = 3) of ^99mTc-HYNIC-D-P8RI in male Wistar rats at 15, 30, 90 min and 24 h post-injection. Columns, mean; bars, SD. (d) RP-HPLC chromatogram (radio detection) of rat urine 90 min p.i; radiochemical purity (RCP) and retention time (t_R) are indicated.