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. 2019 Dec 20;9:19560. doi: 10.1038/s41598-019-56163-x

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Axial, sagittal and coronal views of rats left (saline) and right (Turpentine oil) hind limbs (pink and green regions of interest, respectively) obtained with ^99mTc-HYNIC-D-P8RI (a), ^99mTc-HYNIC-L-P8RI (b) SPECT/CT, and [¹⁸F]FDG PET/MR (c). ^99mTc-HYNIC-D-P8RI and [¹⁸F]FDG uptake was associated with local inflammation compared with a low signal of ^99mTc-HYNIC-L-P8RI. All radiotracers displayed a very low uptake in the contralateral hindlimb (control). Bladder is pointed with a white arrow in (a).