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. 2019 Dec 20;9:19560. doi: 10.1038/s41598-019-56163-x

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Masson’s trichrome staining (a,b,e–l) and autoradiography (c,d) of gastrocnemius muscles 2 days after intramuscular injection of saline (control, left hind limb) or turpentine oil (right hind limb). Animals were sacrificed 1 hour after intravenous ^99mTc-HYNIC-D-P8RI administration. Masson’s trichrome staining in (a) and (b) corresponds to the same slices of autoradiography in (c) and (d). Turpentine injected muscle (a) displays evidence of inflammation with edema and major leukocyte infiltration (e,g,i,k: x1.25, x2.5, x10, x20 respectively), co-localized with a high uptake of ^99mTc-HYNIC-D-P8RI. The representative micrographs (b) corresponds to a control muscle matching with a low uptake of ^99mTc-HYNIC-D-P8RI (d). Higher magnifications of the control show no evidence of inflammation (f,h,j,l).