Figure 3.

The similarity of each hit compound to known Sirtuin 1 inhibitors (see Novelty of the assayed and hit compounds Section) is plotted against the experimental inhibition activity. The error bar represents 95% confidence intervals estimated from IC₅₀ assays. For each point, the category of method used is presented (see Table 1). The similarity in the figure was calculated with the Tanimoto coefficient of the MACCS descriptor⁶⁰.