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. 2019 Dec 20;9:19493. doi: 10.1038/s41598-019-55988-w

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Post-transcriptional reduction of LRAT in FXR-null mice. Whole body FXR-null and wild type mice were analyzed for (A) hepatic mRNA expression of Lrat, Dgat1, Dgat2, Pnpla2 (Atgl), Pnpla3, Lipe (Hsl). Hepatic Lrat and Pnpla3 mRNA levels were increased in FXR-null mice, with no change in other vitamin A metabolizing enzymes as compared to control. Western blot analysis (B) and immunohistochemical staining (C) for LRAT revealed that hepatic protein levels of LRAT were significantly reduced in FXR-null mice as compared to wild-type control mice. Data are presented as Mean ± SEM and mRNA expression of genes is presented in 2^{−delta CT}, which was normalized to 36B4.