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. 2019 Dec 20;9:19493. doi: 10.1038/s41598-019-55988-w

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Cholic acid (0.1%) treatment delays the accumulation of hepatic retinoids in mice. Mice were fed chow or a CA (0.1%)-containing diet for 4, 8 and 12 weeks. (A) Hepatic retinyl palmitate was significantly decreased CA-fed treated mice after 12 weeks as compared to control mice. (B) Hepatic and serum retinol levels did not differ at any time point between both groups of mice. (C) Hepatic mRNA levels FXR-responsive genes Nr0b2 (SHP) and Abcb11 (BSEP) were moderately increased in CA-treated animals compared to control mice. Data are presented as Mean ± SEM and mRNA expression of genes is presented in 2^{−delta CT}, which was normalized to 36B4.