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. 2019 Dec 20;9:19604. doi: 10.1038/s41598-019-55284-7

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Glomerulosclerosis lesions evaluated at days 30 and 60 (400x magnification). The Control group at days 30 (A) and 60 (D) showed a conserved glomerular area. The PAN group presented marked glomerulosclerosis lesions at day 30 (B) that worsened significantly at day 60 (E). Similar glomerulosclerosis lesions were observed in PAN+ mSC at days 30 (C) and 60 (E). Histological scores for glomerulosclerosis in the different groups (G).